United Parkinson's Disease Rating Scale (UPDRS) Data Analyses  

 
   Lead Investigator:    Berneet Kaur
   Institution      :    UC Davis
   E-Mail           :    bekaur@ucdavis.edu
   Proposal ID      :    70


   Publications:


1  Kaur B, Harvey D, DeCarli C, Sabbagh M, Olichney J
   Measurable Parkinsonism in Clinically Diagnosed Alzheimer's Disease: Associated with Mixed Neuropathologies
   Abstract  Neurology,76:A622,2011,

   PUBLISHED



2  Kaur B, Harvey D, DeCarli C, Sabbagh M, Olichney J
   Comparison of extrapyramidal signs (EPS) to dementia severity in Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB)
   Abstract  Alzheimers Dement,6:P2-174,2010,

   PUBLISHED



3  Kaur B, Harvey DJ, DeCarli CS, Zhang L, Sabbagh MN, Olichney JM
   Extrapyramidal signs by dementia severity in Alzheimer disease and dementia with Lewy bodies
   Journal Article  Alzheimer Dis Assoc Disord,27:226-232,2013,PMC3562426

   PUBLISHED





   Proposal Description:
   1. To determine the prevalence of extrapyramidal symptoms (EPS) in Dementia with Lewy Bodies (DLB), Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal elderly (NE). We predict that EPS will be more common and more severe in DLB, followed by AD, MCI and NE.  2. To determine the effect of EPS on the rate of both functional and cognitive decline in DLB, MCI, AD and NE. We predict that the total EPS, as well as specific axial symptoms of EPS, will be associated with faster decline in cognition and functional decline.  3. To determine the clinical factors which best predict the rate of cognitive and functional decline in DLB. We predict that age, degree of specific EPS, and degree of specific neuropsychiatric symptoms will have significant effects upon functional and cognitive decline.